Yu E.A, Zacharias H.U., Kelly S., Vichinsky E.
Improving healthspan among people with sickle cell disease: Leveraging precision health in an era of treatments with curative intent
American Journal of Hematology (2024)

Kolbrink B., Kakavand N., Voran J.C., Zacharias H.U., Rahmel A., Vogelaar S., Schicktanz S., Braun F., Schmitt R., von Samson-Himmelstjerna F.A., Schulte K.
Allocation Rules and Age-Dependent Waiting Times for Kidney Transplantation: An Analysis of Data From the German Transplantation Registry
Deutsches Ärzteblatt International 121 (17) (2024)

Steinbrenner I., Schultheiss U.T., Bächle H., Cheng Y., Behning C., Schmid M., Yeo WJ., Yu B., Grams M.E., Schlosser P., Stockmann H., Gronwald W., Oefner P.J., Schaeffner E., Eckardt K.U., Köttgen A., Sekula P., on behalf of the GCKD Investigators
Associations of Urine and Plasma Metabolites With Kidney Failure and Death in a Chronic Kidney Disease Cohort
American Journal of Kidney Diseases (2024)

Hoefele J., Eble J., Hermle T., Wuttke M., Schultheiss U.T.
Extrarenal manifestations in inherited kidney diseases
Nephrology Dialysis Transplantation (2024)

Schrod S., Lück N., Lohmayer R., Solbrig S., Völkl D., Wipfler T., Shutta K.H., Guebila M.B., Schäfer A., Beißbarth T., Zacharias H.U., Oefner P.J., Quackenbush J., Altenbuchinger M.
SpaCeNet: Spatial Cellular Networks from omics data
Genome Research 34 (9), 1371-1383 (2024)

Schrod S., Zacharias H.U., Beißbarth T., Hauschild A.C., Altenbuchinger M.
CODEX: COunterfactual Deep learning for the in silico EXploration of cancer cell line perturbations
Bioinformatics (2024)

Görtler F., Mensching-Buhr M., Skaar Ø., Schrod S., Sterr T., Schäfer A., Beißbarth T., Joshi A., Zacharias H.U., Grellscheid S.N., Altenbuchinger M.
Adaptive digital tissue deconvolution
Bioinformatics (2024)

Steinbrenne I., Kotsis F., Kosch R., Meiselbach H., Bärthlein B., Stockmann H., Lipovsek J., Zacharias H.U., Altenbuchinger M., Dienemann T., Wytopil M., Bächle H., Sommerer C., Titze S., Weigel A., Weissensteiner H., Schönherr S., Forer L., Kurz N.S., Menne J., Schlieper G., Schneider M.P., Schaeffner E., Kielstein J.T., Sitter T., Floege J., Wanner C., Kronenberg F., Köttgen A., Busch M., Krane V., Schmid M., Eckardt K.U., Schultheiss U.T., the GCKD Investigators
Interactive exploration of adverse events and multimorbidity in CKD
Nephrology Dialysis Transplantation (2024)

von Samson-Himmelstjerna F.A., Bächle H., Kakavand N., Gleske C., Schraml F., Basta A., Braunisch M., Bräsen J.H., Schmitz J., Kraus D., Weinmann-Menke J., Zacharias H.U. et al.
Potential and Uncertainties of RejectClass in Acute Kidney Graft Dysfunction: An Independent Validation Study
Transplantation (2024)

Eble J., Köttgen A., Schultheiss U.T.
Monogenic Kidney Diseases in Adults With Chronic Kidney Disease (CKD).
Deutsches Arzteblatt International (2024)

Sommerer C., Müller-Krebs S., Nadal J., Schultheiss U.T., Friedrich N., Nauck M., Schmid M., Nußhag C., Reiser J., Eckardt K.U., Zeier M., Hayek S.S., on behalf of the German Chronic Kidney Disease Investigators
Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD
Kidney International Reports (2023)

Shutta K.H., Weighill D., Burkholz R., Guebila M.B., DeMeo D.L., Zacharias H.U., Quackenbush J., Altenbuchinger M.
DRAGON: Determining Regulatory Associations using Graphical models on multi-Omic Networks
Nucleic Acids Research (2023)

Funer F., Liedtke W., Tinnemeyer S., Klausen D.A., Schneider D., Zacharias H.U., Langanke M., Salloch S.
Responsibility and decision-making authority in using clinical decision support systems: an empirical-ethical exploration of German prospective professionals’ preferences and concerns
Journal of Medical Ethics (2023)

von Samson-Himmelstjerna F.A., Kolbrink B., Kakavand N., Zacharias H.U., Schulte K.
The German Transplantation Registry Reveals Deficiencies in the Listing Process for Kidney Transplantation
Kidney International Reports (2023)

Brix F., Demetrowitsch T., Jensen-Kroll J., Zacharias H.U., Szymczak S., Laudes M., Schreiber S., Schwarz K.
Evaluating the Effect of Data Merging and Postacquisition Normalization on Statistical Analysis of Untargeted High-Resolution Mass Spectrometry Based Urinary Metabolomics Data
Analytical Chemistry (2023)

Sood M., Suenkel U., von Thaler A., Zacharias H.U., Brockmann K., Eschweiler G.W., Maetzler W., Berg D., Fröhlich H, Heinzel S.
Bayesian network modeling of risk and prodromal markers of Parkinson’s disease
PloS One (2023)

Buck L., Schmidt T., Feist M., Schwarzfischer P., Kube D., Oefner P.J., Zacharias H.U., Altenbuchinger M., Dettmer K., Gronwald W., Spang R.
Anomaly detection in mixed high-dimensional molecular data
Oxford Bioinformatics (2023)

Bächle H., Sekula P., Schlosser P., Steinbrenner I., Cheng Y., Kotsis F., Meiselbach H., Stockmann H., Schönherr S., Eckardt K.U., Devuyst O., Scherberich J., Köttgen A., Schultheiss U.T., GCKD investigators
Uromodulin and its association with urinary metabolites: the German Chronic Kidney Disease Study
Nephrology Dialysis Transplantation (2023)

Steinbrenner I., Yu Z., Jin J., Schultheiss U.T., Kotsis F., Grams M.E., Coresh J., Wuttke M., GCKD Investigators, Kronenberg F., Eckardt K.U., Chatterjee N., Sekula P., Köttgen A.,
A polygenic score for reduced kidney function and adverse outcomes in a cohort with chronic kidney disease
Kidney International (2023)

Schlosser P., Scherer N., Grundner-Culemann F., Monteiro-Martins S., Haug S., Steinbrenner I., Uluvar B., Wuttke M., Cheng Y., Ekici A.B., Gyimesi G., Karoly E.D., Kotsis F., Mielke J., Gomez M.F., Yu B., Grams M.E., Coresh J., Boerwinkle E., Köttgen M., Kronenberg F., Meiselbach H., Mohney R.P., Akilesh S., GCKD Investigators, Schmidts M., Hediger M.A., Schultheiss U.T., Eckardt K.U., Oefner P.J., Sekula P., Li Y., Köttgen A.
Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine
nature genetics (2023)

Ruhe J., Nadal J, Bärthlein B., Meiselbach H., Schultheiss U.T., Kotsis F., Stockmann H., Krane V., Sommerer C., Löffler I., Saritas T., Kielstein J.T., Sitter T., Schneider M.P., Schmid M., Wanner C., Eckardt K.U., Wolf G., Busch M.
Cardiovascular risk due to diabetes mellitus in patients with chronic kidney disease—prospective data from the German Chronic Kidney Disease cohort
Clinical Kidney Journal (2023)

Reimer K.C., Nadal J., Meiselbach H., Schmid M., Schultheiss U.T., Kotsis F., Stockmann H., Friedrich N., Nauck M., Krane V., Eckardt K.U., Schneider M.P., Kramann R., Floege J., Saritas T.
Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease (GCKD) cohort
Bone Research (2023)

Schumann A., Schultheiss U.T., Ferreira C.R., Blau N.,
Clinical and biochemical footprints of inherited metabolic diseases. XIV. Metabolic kidney diseases
Molecular Genetics and Metabolism (2023)

Cejka V., Störk S., Nadal J., Schmid M., Sommerer C., Sitter T., Meiselbach H., Busch M., Schneider M.P., Saritas T., Schultheiss U.T., Kotsis F., Wanner C., Eckardt K.U., Krane V., GCKD Study Investigators
Differential Prognostic Utility of Adiposity Measures in Chronic Kidney Disease
Molecular Genetics and Metabolism (2023)

Kotsis F. , Bächle H. Altenbuchinger M., Dönitz J., Njipouombe N.Y.A., Meiselbach H., Kosch R., Salloch S., Bratan T., Zacharias H.U., Schultheiss U.T.
Expectation of clinical decision support systems: a survey study among nephrologist end-users
BMC Medical Informatics and Decision Making Volume 23, article number 239, (2023)

Zacharias H.U., Altenbuchinger M., Schultheiss U.T. et al.
A Predictive Model for Progression of CKD to Kidney Failure Based on Routine Laboratory Tests
American Journal of Kidney Diseases, 79(2): 217-230.e1 (2022)

Kheirkhah A., Lamina C., Kollerits B., Schachtl-Riess J., Schultheiss U.T., Forer L., Sekula P., Kotsis F., Eckardt K.U., Kronenberg F.
PCSK9 and Cardiovascular Disease in Individuals with Moderately Decreased Kidney Function
Clinical Journal of American Society of Nephrology (2022)

Altenbuchinger M., Berndt H., Kosch R., Lang I., Dönitz J., Oefner P.J., Gronwald W., Zacharias H.U., Investigators GCKD Study
Bucket Fuser: Statistical Signal Extraction for 1D 1H NMR Metabolomic Data
Metabolites (2022)

Zacharias H.U., Kaleta C., Cossais F., Schaeffer E., Berndt H., Best L., Dost T., Glüsing S., Groussin M., Poyet M., Heinzel S., Bang C., Siebert L., Demetrowitsch T., Leypoldt F., Adelung R., Bartsch T., Bosy-Westphal A., Schwarz K., Berg D.
Microbiome and Metabolome Insights into the Role of the Gastrointestinal–Brain Axis in Parkinson’s and Alzheimer’s Disease: Unveiling Potential Therapeutic Targets
Metabolites (2022)

Mielke J., Trucks-Jansen H., Schurmann C., Kotsis F., Köttgen A., Schneider M.P, Eckardt K.U., GCKD Investigators, Freitag D.F., Eitner F., Becker M.S.
Prevalence, phenotypic characteristics and prognostic role of apparent treatment resistant hypertension in the German Chronic Kidney Disease (GCKD) study
Journal of Human Hypertension (2022)

Kotsis F., Steinbrenner I., Lipovsek J., Stockmann H., Schultheiss U.T., GCKD Investigators
Incident Events and Their Combinations After 6.5 Years of Follow-Up in the German Chronic Kidney Disease Study
Journal of the American Society of Nephrology (JASN) (2022)

Surendran P., Stewart .I.D., AU Yeung V.P.W., Pietzner M., Raffler J. et al.
Rare and common genetic determinants of metabolic individuality and their effects on human health
nature medicine (2022)

Schrod S., Schäfer A., Solbrig S., Lohmayer R., Gronwald W., Oefner P. J., Beißbarth T., Spang R., Zacharias H.U., Altenbuchinger M.
BITES: Balanced Individual Treatment Effect for Survival data
Bioinformatics (Oxford Academic), (2022)

Guebila M.B., Weighill D., Lopez-Ramos C.M., Burkholz R., Pop R.T., Palepu K., Shapoval M., Fagny M., Schlauch D., Glass K., Altenbuchinger M. et al.
An online notebook resource for reproducible inference, analysis and publication of gene regulatory networks
Nature Methods (2022)

Lotta L.A., Pietzner M., Stewart I.D., Wittemans L.B.L., Li C., Bonelli R., Raffler J. et al.
A cross-platform approach identifies genetic regulators of human metabolism and health
Nature Genetics (2021)

Pietzner M., Stewart I.D., Raffler J. et al.
Plasma metabolites to profile pathways in noncommunicable disease multimorbidity
Nature Genetics (2021)

Zacharias H.U., Hertel J., Johar H. et al.
A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression
Molecular Psychiatry volume 26, pages 7372–7383 (2021)

Schultheiss U.T., Kosch R., Kotsis F. et al.
Chronic Kidney Disease Cohort Studies: A Guide to Metabolome Analyses
Metabolites 11(7), 460; (2021)

Winitzki D., Zacharias H.U., Nadal J. et al.
Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort
Kidney International Reports VOLUME 7, ISSUE 5, P1004-1015, MAY (2022)

Cheng Y., Li Y., Scherer N., Grundner-Culemann F., Lehtimäki T., Mishra B.H., Raitakari O.T., Nauck M., Eckardt K., Sekula P., Schultheiss U.T. et al.
Genetics of osteopontin in patients with chronic kidney disease: The German Chronic Kidney Disease study
PloS Genetics April 6 (2022)

Li Y., Cheng Y., Consolato F., Schiano G., Chong M.R., Pietzner M., Nguyen N.G.H., Scherer N., Biggs M.L., Kleber M.E., Haug S., Göçmen B., Pigeyre M., Sekula P., Steinbrenner I., Schlosser P., Joseph CB., Brody J.A., Grams M.E., Hayward C., Schultheiss U.T. et al.
Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases
Journal of Clinical Investigation Insight (2022)

Steinbrenner I., Sekula P., Kotsis F. et al.
`Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study
Nephrology Dialysis Transplantation (2021)

Steinbrenner I., Schultheiss U.T., Kotsis F. et al.
Urine Metabolite Levels, Adverse Kidney Outcomes, and Mortality in CKD Patients: A Metabolome-wide Association Study
American Journal of Kidney Diseases (2021)

Kotsis F., Schultheiss U.T. et al.
Self-Reported Medication Use and Urinary Drug Metabolites in the German Chronic Kidney Disease (GCKD) Study
Journal of the American Society of Nephrology (JASN) (2021)

Pammer L.M, Lamina C., Schultheiss U.T., Kotsis F. et al.
Association of the metabolic syndrome with mortality and major adverse cardiac events: A large chronic kidney disease cohort
Journal Internal Medicine (JIM) (2021)

Schultheiss U.T., Peggy S.
The Promise of Metabolomics in Decelerating CKD Progression in Children
Clinical Journal of the American Society of Nephrology (CJASN) (2021)

Bonk S., Hertel J., Zacharias H.U. et al.
Vitamin D moderates the interaction between 5‑HTTLPR and childhood abuse in depressive disorders
Scientific reports (2020)

Schultheiss U.T. et al.
Thyroid function, renal events and mortality in chronic kidney disease patients: the German Chronic Kidney Disease study
Clinical Kidney Journal, sfaa052 (2020)

Sekula P., Tin A., Schultheiss U.T. et al.
Urine 6-Bromotryptophan: Associations with Genetic Variants and Incident End-Stage Kidney Disease
Sci Rep 10, 10018 (2020)

Pietzner M., Wheeler E., Carrasco-Zanini J., Raffler J. et al.
Genetic architecture of host proteins interacting with SARS-CoV-2
Preprint at bioRxiv (2020)

Altenbuchinger M., Zacharias H.U., Solbrig S. et al.
A multi-source data integration approach reveals novel associations between metabolites and renal outcomes in the German Chronic Kidney Disease study
Sci Rep 9, 13954 (2019)

Zacharias H.U., Altenbuchinger M., Schultheiss U.T. et al.
A novel metabolic signature to predict the requirement of dialysis or renal transplantation in patients with chronic kidney disease
J. Proteome Res. 2019, 18, 4, 1796-1805 (2019)

Schlosser P., Li Y., Sekula P., Raffler J. et al.
Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans
Nat Genet 52, 167–176 (2020)

Fazzini F., Lamina C., Raschenberger J., Schultheiss U.T., Kotsis F.
Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease
Kidney International (2020)